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Related post: Ck (b) Human tissues D (c) NeitherSUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided.)The mechanisms of activation , proliferation , and differentiation of human B cellswere studied. Particular attention was paid to the factors operative in the B eelcycle . A high molecular weight B cell growth factor (HMW-BCGF) was identified,isolated, characterized, and purified to homogeneity . Its specific binding toactivated B cells was demonstrated. A monoclonal antibody directed againstHMW-BCGF was produced which specifically inhibited the activity of the factor,specifically bound to the factor, and specifically absorbed out Generic Bromocriptine the factor fromculture supernatants. The production of BCGF by normal B cells and malignant Bcell lines was demonstrated suggesting an autocrine function for this factor.Interleukin-2 (IL-2) receptors were demonstrated on activated B cells and IL-2 wasdemonstrated to play a major role in the proliferation and differentiation ofhuman B cells. y-Interferon synergized with IL-2 in the induction of differen-tiation of B cells. The phenotypic expression of certain T cell clones werecorrelated with defined functional capabilities of the clone in Bromocriptine Online the regulationof B cell function, particularly via production of B cell differentiation factor(BCOF). Human T cell clones and normal B cells were transformed with human Tlymphotropic virus (HTLV-I) and used as a model system for the delineation ofcertain lymphoid cell functions such as the expression of IL-2 receptors and theresponse to IL-2. The pharmacologic modulation of the human immune response wasstudied Buy Bromocriptine particularly with regard to the effects of corticosteroids , cyclosporin A ,transforming growth factor-p , and certain neuropeptides on certain distinct phasesof the Order Bromocriptine human B cell cycle.6-16PHS 6040 (Rev. 1/84)GPo 914-aieothers: H. Clifford LaneDebra L. BowenShoken TomitaNaoko NakagawaToshimasa NakagawaLe thi Bich-ThuySenior Staff FellowMedical Staff FellowVisiting FellowVisiting FellowVisiting FellowVisiting FellowLIR, NIAIDLIR, NIAIDLIR, NIAIDLIR, NIAIDLIR, NIAIDLIR, NIAID6-17DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICENOTICE OF INTRAMURAL RESEARCH PROJECTPROJECT NUMBERZOl AI 00211-04 LIRPERIOD COVEREDOctober 1, 1984 to September 30, 1985TITLE OF PROJECT (80 characters or less. Title must fit on one line between the borders.)Study of Human Lymphocyte Subsets Employing Cloning and Hybridoma TechnologyPRINCIPAL INVESTIGATOR (List other professional personnel below Buy Bromocriptine Online the Principal Investigator.) (Name, title, laboratory, and institute affiliation)PI: Purchase Bromocriptine Anthony S. Fauci Chief LIR, NIAIDCOOPERATING UNITS (if any)LAB/BRANCHLaboratory of ImmunoregulationSECTIONINSTITUTE AND LOCATIONNIAID, NIH. Bethesda, Maryland 20205TOTAL MAN-YEARS:PROFESSIONAL:OTHER:CHECK APPROPRIATE BOX(ES)D (a) Human subjectsn (a1) MinorsD (a2) InterviewsD (b) Human tissues D (c) NeitherSUMMARY OF WORK (Use standard Order Bromocriptine Online unreduced type. Do not exceed the space provided.)Project terminated.6-18PHS 6040 (Rev. 1/84)GPO gi4-8l8DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICENOTICE OF INTRAMURAL RESEARCH PROJECTPROJECT NUMBERZOl AI 00212-05 LIRPERIOD COVEREDOctober 1, 1984 to September 30, 1985TITLE OF PROJECT (80 characters or less. Title must fit on one line between the borders.)Study of the Immunopathogenic Features of Immune-Mediated DiseasesPRINCIPAL INVESTIGATOR (List Purchase Bromocriptine Online other professional personnel below the Principal Investigator.) (Name, title, laboratory, and institute affiliation)PI: Anthony S. Fauci Chief LIR, NIAIDOthers: Joseph B. MargolickH. Clifford LaneDavid J. VolkmanAnthony P. WeetmanAlain H. RookMedical Staff FellowSenior InvestigatorSenior InvestigatorGuest Researcher